Saturday, June 16, 2007

Progen Research Lab

Research and development in the field of welknown Ancient Indian Medicine “Ayurveda”

The Progen Research Lab is based in Belgaum, Karnataka is in Research & Development, Manufacturing as well as in Marketing of Ayurvedic Remedial products.

The Company has inherent heritage of Ayurveda. Over a span of eighteen years it is researching on different challenging common ailments like Infertility, Diabetes, Arthritis, Skin disorders, Liver Disorders, Obesity and Urinary Stones etc. The company has recently developed a remedy in the form of Capsule as a supporting tool in treatment of male infertility, which is already existing in the Indian Market.

Progen Research Lab is adding feather to its cap by developing few more products which will be an answer for challenges led by ailments like Diabetes mellitus, Rheumatoid Arthritis.

22 comments:

Bento Carlos said...

I am very interested on try your remedies. There is a possibility of distribute then all over Brazil and South America.

JC said...

Thanks for all you have done for me! He has helped me heal my gastritis with a routine of great herbs. What a wonderful person and doctor. Real kind hearted and willing to help others, Im in the USA and he was willing to find a way to provide the best of care!!! Thanks to him I can now live without stomach pains.

NARU said...

Dr. Srinivas is a very good doctor and his medicine Progen capsules helped me a lot in increasing my Sperm Count drastically. Before I started his medicine my count was only 8 mill/ ml and the same increased to 24 mill / ml after having one month course of Progen Capsules.

Shanthi said...

Can u please tell how to get this tablets to my husband. my mail id is anbudan.shanthi@gmail.com

Raj said...

Hi,

Is there a permanent cure for acute pancreatitis in ayurvedha, as i do not see any resolutions since 10 years.

Regards,
Raj.

Shrinivas said...

Pancreatitis is very complicated entity and as per the cure is concerned it depends on the causes of it, one can control the attacks of pancreatitis and and complication by control over diet and life style, AYURVEDA describes it as a PITTA dosha Disease. One has to develop regularity in life style pertaining to time of food, sleep, quantity of food, and lastly quality of food, NON vegitarian food can be a major cause to errupt the problem of acute pancreatitis.

a said...

Hallo
My Sperm count is less than 20 million / ml. I am suffering from sterility since 10 years of my marriage.
Can you tell me how much improvement is possible after progen treatment.
Do you have clinical trials to suggest improvement in sterility in percentage ??

Awaiting for your answer

Mr. A from Pune

Shrinivas said...

Hello Mr A, I came accross your comment recently, as you said you are suffering from infertility since 10 years and your count is 20 millions per ml , I would like to say on this that along with count the motility and morphology is also important to normalise semen, if you have only less count and other things are normal then Progen Capsule 1 capsule twice in a day for atleast 60 days can increase your count up to 40illions / ml or more than this and you can continue your treatment till your wife get concieved.

Shrinivas said...

Mr A about clinical Data you asked
in pilot study on 30 prediagnosed patients of oligospermia( already treated with available treatment till date and no improvement)were selected and treated with progen capsules out of them 25 patients were (83.33%) reported normal counts in there semen parameters. 3 reported improment but no normalcy is achieved (10%) and 2 were reported no improvement in the previous conditions(7%) . regarding pregnancy reporting of their wives ( which is the altemate aim of the infertility treatment) 17 patients out 30 reported pregnancy of their wives. (56.66%) whcih is quite significant ( here no assessment was done for any gynaec foctor- it was random)

Shrinivas said...

Hello , every one are allowed to put their queries and comments

ANNA NOEL said...

Im a herbal medicine consumer. I was able to browse your website through Dr. Patil and get interested in your product NERVONO(remedy for stress induced mental disorder). I’ve been connected in kind a stressful task which is in sales/marketing dept. After using it for sometime i noticed that it worked so well with me, now I experienced sound sleep, more relaxed, energized the next day and because of stress and anxiety I lost my ability to concentrate and had some short term memory problems, NERVONO help me focus so much better. The only side effects I come across with NERVONO have been good ones. I used other herbal before same function as this but I could say that yours suits my needs perfectly. For this reason, I shared it with my friend who suffered insomnia I gave her few capsules and after 3 days she told me it certainly helps her sleep and felt really good with it so from then on she ordered few bottles for her regular consumption.

Dr. Patil thank you very much for sharing this gift of health product. I look forward that you will have official distributor here in the Philippines(Asia) so we can easily order your products.

Shrinivas said...

hello Ana thank you for you feedback , yes definately we will be intrested to have our official out let at phillipines provided some one is intrested to have distributorship, any one is welcome, if intrested - Regards Dr Shrinivas Patil

Shrinivas Patil said...

Male infertility : Infertility is defined as the inability to achieve pregnancy after one year of unprotected intercourse. An estimated 15% of couples meet this criterion and are considered infertile, with approximately 35% due to female factors alone, 30% due to male factors alone, 20% due to a combination of female and male factors, and 15% unexplained. Conditions of the male that affect fertility are still generally underdiagnosed and undertreated.

Causes of infertility in men can be explained by deficiencies in sperm formation, concentration (eg, oligospermia [too few sperm], azoospermia [no sperm in the ejaculate]), or transportation. This general division allows an appropriate workup of potential underlying causes of infertility and helps define a course of action for treatment.

The initial evaluation of the male patient should be rapid, noninvasive, and cost-effective, as nearly 70% of conditions that cause infertility in men can be diagnosed with history, physical examination, and hormonal and semen analysis alone. More detailed, expensive, and invasive studies can then be ordered if necessary.

Treatment options are based on the underlying etiology and range from optimizing semen production and transportation with medical therapy or surgical procedures to complex assisted reproduction techniques. Technological advancements make conceiving a child possible with as little as one viable sperm and one egg. Although the workup was traditionally delayed until a couple was unable to conceive for 12 months, evaluation may be initiated at the first visit in slightly older couples.

Shrinivas Patil said...

Pathophysiology in Male Infertility

Gonadal and sexual functions are mediated by the hypothalamic-pituitary-gonadal axis, a closed-loop system with feedback control from the testicles. The hypothalamus, the primary integration center, responds to various signals from the CNS, pituitary gland, and testicles to secrete gonadotropin-releasing hormone (GnRH) in a pulsatile pattern approximately every 70-90 minutes. The half-life of GnRH is 2-5 minutes. Release of GnRH is stimulated by melatonin from the pineal gland and inhibited by testosterone, inhibin, corticotropin-releasing hormone, opiates, illness, and stress. GnRH travels down the portal system to the anterior pituitary, located on a stalk in the sella turcica, to stimulate the release of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH).
Male infertility. Hypothalamic-pituitary-gonadal aMale infertility. Hypothalamic-pituitary-gonadal axis stimulatory and inhibitory signals. Gonadotropin-releasing hormone (GnRH) from the hypothalamus stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. FSH stimulates the Sertoli cells to facilitate sperm production, while LH stimulates testosterone release from the Leydig cells. Feedback inhibition is from testosterone and inhibin.

FSH and LH, glycopeptides with a molecular weight of 10,000 daltons, are each composed of an alpha chain that is identical to that of human chorionic gonadotropin (HCG) and thyroid-stimulating hormone (TSH), but with a beta chain that is unique for each. FSH has a lower plasma concentration and longer half-life than LH, and it has less obvious pulsatile changes. The pulsatile nature of GnRH is essential to normal gonadotropin release; a continuous stimulation inhibits their secretion.

The hypothalamus also produces thyrotropin-releasing hormone (TRH) and vasoactive intestinal peptide (VIP), both of which stimulate prolactin release from the anterior pituitary, and dopamine, which inhibits prolactin release. Men with elevated prolactin levels present with gynecomastia, diminished libido, erectile dysfunction, and occasionally galactorrhea. Prolactin inhibits the production of GnRH from the hypothalamus and LH and FSH from the pituitary. Gonadotropin release is modulated by various other signals, such as estradiol (a potent inhibitor of both LH and FSH release), and inhibin from the Sertoli cell, which causes a selective decrease in FSH release.

Shrinivas Patil said...

FSH and LH are released into system circulation and exert their effect by binding to plasma membrane receptors of the target cells. LH mainly functions to stimulate testosterone secretion from the Leydig cells of the testicle, while FSH stimulates Sertoli cells to facilitate germ cell differentiation.

Testosterone is secreted in a diurnal pattern, peaking early in the morning. In the body, testosterone circulates 2% in the free form, 44% bound to sex hormone–binding globulin (SHBG), and 54% bound to albumin. Testosterone is converted to dihydrotestosterone (DHT) by the action of 5-alpha reductase, both locally and in the periphery, and to estrogen in the periphery. Testosterone and estradiol function as feedback inhibitors of gonadotropin release.

The testicle contains the Leydig cells and the Sertoli cells and is covered by the tunica albuginea, which also provides septae that divide it into approximately 200-350 pyramids. These pyramids are filled with the seminiferous tubules. A normal testicle contains 600-1200 seminiferous tubules with a total length of approximately 250 meters. The interstitium between the seminiferous tubules contains the Leydig cells, fibroblasts, lymphatics, blood vessels, and macrophages. Histologically, Leydig cells are polygonal with eosinophilic cytoplasm. Occasionally, the cytoplasm contains crystalloids of Reinke after puberty.
Male infertility. Testicular histology magnified 5Male infertility. Testicular histology magnified 500 times. Leydig cells reside in the interstitium. Spermatogonia and Sertoli cells lie on the basement membrane of the seminiferous tubules. Germ cells interdigitate with the Sertoli cells and undergo ordered maturation, migrating toward the lumen as they mature.

Seminiferous tubules are made up of Sertoli cells and germ cells and are surrounded by peritubular and myoid cells.

Sertoli cells are columnar, with irregular basal nuclei that have prominent nucleoli and fine chromatin. They rest on the basement membrane and serve mainly to support, nourish, and protect the developing germ cells and to provide a blood-testis barrier to provide a microenvironment that facilitates spermatogenesis and maintains the germ cells in an immunologically privileged location. Sertoli cells also secrete inhibin, which provides negative feedback on the hypothalamus, and androgen-binding protein, which helps modulate androgen activity in the seminiferous tubules. In addition to FSH, Sertoli cell function is modulated by intratesticular testosterone and signals from peritubular myoid cells.

Shrinivas Patil said...

Germ cells (precursors to spermatozoa) are derived from the gonadal ridge and migrate as gonadocytes to the testicle before testicular descent. In response to FSH stimulation at puberty, germ cells become spermatogonia and undergo an ordered maturation to become spermatozoa. The entire process of development from spermatogonium to spermatid takes 74 days and is described in 14 steps; as they mature, the developing spermatids progress closer to the lumen of the seminiferous tubule.

Spermatogonia rest on the basement membrane and contain dense nuclei and prominent nucleoli. Three types are described: A dark (Ad), A pale (Ap), and B cells. Ad cells (stem cells) divide to create more Ad cells (stem cell renewal) or differentiate into daughter Ap cells every 16 days. Ap cells mature into B spermatogonia, which then undergo mitotic division to become primary spermatocytes, which are recognized by their large centrally located nuclei and beaded chromatin. The mitotic division does not result in complete separation; rather, daughter cells maintain intracellular bridges, which have functional significance in cell signaling and maturation.

Primary spermatocytes undergo meiosis as the cells successively pass through the preleptotene, leptotene, zygotene, and pachytene stages to become secondary spermatocytes. During this time, the cells cross from the basal to the adluminal compartments. Secondary spermatocytes contain smaller nuclei with fine chromatin. The secondary spermatocytes undergo a second meiosis and become spermatids. This reduction division (ie, meiosis) results in a haploid chromosome number. Therefore, a total of 4 spermatids are made from each spermatocyte.

Next, the spermatids undergo the process of spermiogenesis (through stages named Sb1, Sb2, Sc, Sd1, and Sd2), which involves the casting of excess cytoplasm away as a residual body, the formation of the acrosome and flagella, and the migration of cytoplasmic organelles to their final cellular location. The acrosome, a derivative of the Golgi process, surrounds the nucleus anteriorly and contains enzymes necessary to penetrate the ovum. The mature spermatid is then located adjacent to the tubule lumen and contains dark chromatin with an oval-shaped nucleus.

After their release from the Sertoli cells into the lumen of the seminiferous tubules, the spermatids successively pass through the tubuli recti, rete testis, ductuli efferentes, and, finally, the epididymis. The epididymis is a 3- to 4-cm long structure with a tubular length of 4-5 m. As sperm move from the head to the tail, they mature and acquire fertilization capacity. Sperm from the head move with immature wide arcs and are generally unable to penetrate the egg, while those from the tail propel forward and have better penetration capacity. The transit time varies with age and sexual activity but is usually from 1-12 days. The epididymis additionally secretes substances for sperm nutrition and protection such as glycerophosphorylcholine, carnitine, and sialic acid.

Shrinivas Patil said...

Sperm next enter the vas deferens, a 30- to 35-cm muscular conduit of Wolffian duct origin. The vas is divided into the convoluted, scrotal, inguinal, retroperitoneal, and ampullary regions and receives its blood supply from the inferior vesicle artery. In addition to functioning as a conduit, the vas also has absorptive and secretory properties. During emission, sperm are propelled forward by peristalsis. After reaching its ampullary portion behind the bladder, the vas joins with the seminal vesicles, at the ejaculatory duct, which empties next to the verumontanum of the prostate. During ejaculation, the ejaculate is propelled forward by the rhythmic contractions of the smooth muscle that surrounds the ducts and by the bulbourethral muscles and other pelvic muscles. Bladder neck closure during ejaculation is vital to ensure antegrade ejaculation.

Normal ejaculate volume ranges from 1.5 to 5 mL and has a pH level of 7.05-7.8. The seminal vesicles provide 40-80% of the semen volume, which includes fructose for sperm nutrition, prostaglandins and other coagulating substances, and bicarbonate to buffer the acidic vaginal vault. Normal seminal fructose concentration is 120-450 mg/dL, with lower levels suggesting ejaculatory duct obstruction or absence of the seminal vesicles. The prostate gland contributes approximately 10-30% (0.5 mL) of the ejaculate. Products include enzymes and proteases to liquefy the seminal coagulum. This usually occurs within 20-25 minutes. The prostate also secretes zinc, phospholipids, phosphatase, and spermine. The testicular-epididymal component includes sperm and comprises about 5% of the ejaculate volume.

In addition to the components already listed, semen is also composed of secretions from the bulbourethral (Cowper) glands and the (periurethral) glands of Litre, each producing 2-5% of the ejaculate volume, serving mainly to lubricate the urethra and to buffer the acidity of the residual urine. The ordered sequence of release is important for appropriate functioning.

For conception, sperm must reach the cervix, penetrate the cervical mucus, migrate up the uterus to the fallopian tube, undergo capacitation and the acrosome reaction to digest the zona pellucida of the oocyte, attach to the inner membrane, and release its genetic contents within the egg. The cervical mucus changes consistency during the ovulatory cycle, being most hospitable and easily penetrated at mid cycle. After fertilization, implantation may then take place in the uterus. Problems with any of these steps may lead to infertility.

Sr said...

Thank you so much for the suvarna vacahadi yog. It worked really well for my son who was not talking. After suvarana vacahadi yog, he started talking more and more everyday.

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Shrinivas Patil said...

Progen Research Labs story covered in Gulf News GN Focus article on 26th Jan.2014 here is the link
http://gulfnews.com/gn-focus/india/chasing-green-1.1280208

Leave your comments below
Dr Shrinivas
Progen Research Lab.

Arpu Kasuganti said...

Hi my son is 30 month old but not talking yet will sugar a vachadi yog help him speak

Arpu Kasuganti said...

Hi my son is 30 month old but not talking yet will suvarna vachadi yog help him speak better please let me know as early as you can or can you please send me email to arpu9802@gmail.com